Clinical trial: Phase I Dose Escalation completed successfully with exciting results

To date, 15 patients with advanced/metastatic solid tumors have been enrolled (3+3 protocol).

• Toxicity: MTD has not been reached. Treatment was well-tolerated with no cumulative toxicity.

• Pharmacokinetic analysis: AUC, Cmax and t½ were calculated and were dose-dependent and approximately linear.

• Efficacy: 5 of 15 evaluable patients have been treated for at least 3 cycles and were considered SD through this period.

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